Thus, if the daily needs of B12 are approximately 2 μg, administering oral supplements at high doses (1-2 mg) once a day can achieve a sufficient amount to ensure the values and filling of the tissue stores through passive intestinal absorption. Several studies have shown that the small percentage (1-2%) of vitamin that is passively absorbed in the intestine could be sufficient to achieve, with high doses of vitamin B12, adequate concentrations in the body, even in cases of absence of IF by pernicious anemia or gastrectomy, achlorhydria, malabsorption or lack of integrity of the terminal ileum. There is abundant accumulated evidence that the replacement of B12 can be carried out effectively orally. This treatment does not usually produce adverse effects, but it involves repeated visits, discomforts and risks in relation to the use of the parenteral route. The most usual regimen consists of daily doses of 1,000 μg for one week, followed by weekly injections for 4 weeks and, then, monthly. The administration of vitamin B12 to correct or prevent the deficiency is usually for life, and has traditionally been prescribed in the form of intramuscular injections. Vitamin B12 passes into the bloodstream bound to transcobalamin II, which transports it to the liver and other areas of the body.
The B12-FI complex binds to the ileal cell receptors and is absorbed by endocytosis. It is absorbed in the distal ileum, after passing through the small intestine linked to the intrinsic factor (IF), a protein synthesized in the parietal cells of the gastric fundus. The vitamin ingested in the diet is separated from animal proteins by pepsin and gastric hydrochloric acid, joining haptocorrin, a protein of salivary origin, which is dissociated in the duodenum by the action of pancreatic proteases. The human organism is not able to synthesize it and must obtain it from the diet, mainly from foods of animal origin (meat, milk and derivatives, eggs, fish). Vitamin B12 or cobalamin plays a key role as a coenzyme in DNA synthesis and cell maturation, as well as in the synthesis of neuronal lipids. The daily dose of 1 mg (1000 mcg) oral cobalamin has shown good long-term results the possibility of intermittent maintenance guidelines is investigated. These products are not intended to diagnose, treat, cure or prevent any disease.Is It OK To Take 1000 mcg of Vitamin B12 a Day? These statements have not been evaluated by the Food and Drug Administration.Made with high quality ingredients, these Nature Made Vitamin B12 Tablets have no color added, no artificial flavors and no preservatives.Adults take one of these Nature Made B12 timed release tablets daily with water and a meal.This Nature Made B12 supplement is also important for vegetarians and vegans who may not consume enough from diet alone.Nature Made B12 1000 mcg are dietary supplements that help break down food into energy that your body can use all day long.Energy metabolism support supplement: contains one 160 count bottle of Nature Made Vitamin B12 1000 mcg Time Release Tablets for a 160-day supply(1).Based on a survey of pharmacists who recommend branded vitamins and supplements. (1)Helps convert food into cellular energy. Nature Made supplements are quality you can trust. Adults take one of these Nature Made Vitamin B12 Time Release Tablets daily with water and a meal. This Vitamin B12 supplement also features a time release formula that extends vitamin absorption by the body. B12 vitamins are important for vegetarians and vegans who may not consume enough from diet alone.
Nature Made Vitamin B12 helps support energy metabolism(1).
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